clomipramine decreases effects of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep an eye on. Stops conversion of codeine to its active metabolite morphine.
Given that 2019, there are already increasing studies within the media of codeine linctus remaining misused being an component within a recreational drink, commonly called ‘Purple Drank’.
chloroquine will increase the degree or impact of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Helps prevent conversion of codeine to its Lively metabolite morphine.
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Children are particularly sensitive into the respiratory depressant results of codeine; on account of risk of existence-threatening respiratory despair and Demise, using codeine goods is contraindicated in little ones a lot less than 12 a long time of age, and in pediatric people young than 18 yrs of age subsequent tonsillectomy and/or adenoidectomy
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